17-Aminogeldanamycin Inhibits Constitutive Nuclear Factor-Kappa B (NF-κB) Activity in Patient-Derived Melanoma Cell Lines

Melanoma remains incurable skin cancer, and targeting heat shock protein 90 (HSP90) is a promising therapeutic approach. In this study, we investigate the effect of 17-aminogeldanamycin, a potent HSP90 inhibitor, on nuclear factor-kappa B (NF-κB) activity in BRAF(V600E) and NRAS(Q61R) patient-derive...

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Detalles Bibliográficos
Autores principales: Hartman, Mariusz L., Rogut, Magdalena, Mielczarek-Lewandowska, Aleksandra, Wozniak, Michal, Czyz, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312877/
https://www.ncbi.nlm.nih.gov/pubmed/32466509
http://dx.doi.org/10.3390/ijms21113749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312877/
https://www.ncbi.nlm.nih.gov/pubmed/32466509
http://dx.doi.org/10.3390/ijms21113749

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