Reduction in BDNF from Inefficient Precursor Conversion Influences Nest Building and Promotes Depressive-Like Behavior in Mice

We generated a knock-in mouse line in which the gene encoding brain-derived neurotrophic factor (Bdnf) was replaced with a sequence for proBDNF containing human single nucleotide polymorphisms encoding arginines proximal to the cleavage site (R125M and R127L). The ratio of the mature form of BDNF (m...

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Detalles Bibliográficos
Autores principales: Kojima, Masami, Otabi, Hikari, Kumanogoh, Haruko, Toyoda, Atsushi, Ikawa, Masahito, Okabe, Masaru, Mizui, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312902/
https://www.ncbi.nlm.nih.gov/pubmed/32492978
http://dx.doi.org/10.3390/ijms21113984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312902/
https://www.ncbi.nlm.nih.gov/pubmed/32492978
http://dx.doi.org/10.3390/ijms21113984

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