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Apelin-13 Inhibits Methylglyoxal-Induced Unfolded Protein Responses and Endothelial Dysfunction via Regulating AMPK Pathway

It has been suggested that methylglyoxal (MGO), a glycolytic metabolite, has more detrimental effects on endothelial dysfunction than glucose itself. Recent reports showed that high glucose and MGO induced endoplasmic reticulum (ER) stress and myocyte apoptosis in ischemic heart disease was inhibite...

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Detalles Bibliográficos
Autores principales: Kim, Sujin, Kim, Suji, Hwang, Ae-Rang, Choi, Hyoung Chul, Lee, Ji-Yun, Woo, Chang-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313041/
https://www.ncbi.nlm.nih.gov/pubmed/32517197
http://dx.doi.org/10.3390/ijms21114069