Human Neural Stem Cells Encoding ChAT Gene Restore Cognitive Function via Acetylcholine Synthesis, Aβ Elimination, and Neuroregeneration in APPswe/PS1dE9 Mice

In Alzheimer disease (AD) patients, degeneration of the cholinergic system utilizing acetylcholine for memory acquisition is observed. Since AD therapy using acetylcholinesterase (AChE) inhibitors are only palliative for memory deficits without slowing or reversing disease progress, there is a need...

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Detalles Bibliográficos
Autores principales: Park, Dongsun, Choi, Ehn-Kyoung, Cho, Tai-Hyoung, Joo, Seong Soo, Kim, Yun-Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313059/
https://www.ncbi.nlm.nih.gov/pubmed/32486466
http://dx.doi.org/10.3390/ijms21113958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313059/
https://www.ncbi.nlm.nih.gov/pubmed/32486466
http://dx.doi.org/10.3390/ijms21113958

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