Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor...

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Detalles Bibliográficos
Autores principales: Jin, Xiao, Dai, Lu, Ma, Yilan, Wang, Jiayan, Liu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313137/
https://www.ncbi.nlm.nih.gov/pubmed/32587480
http://dx.doi.org/10.1186/s12935-020-01370-0
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author Jin, Xiao
Dai, Lu
Ma, Yilan
Wang, Jiayan
Liu, Zheng
author_facet Jin, Xiao
Dai, Lu
Ma, Yilan
Wang, Jiayan
Liu, Zheng
author_sort Jin, Xiao
collection PubMed
description Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in an oxygen-deficient tumor microenvironment. Numerous studies revealed the central role of HIF-1α in the carcinogenesis and progression of pancreatic cancer. This article reviewed the molecular mechanisms of how HIF-1α regulated tumorigenesis and progression of pancreatic cancer and suggested that targeting HIF-1α and its signaling pathways could be promising therapeutics for pancreatic cancer.
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spelling pubmed-73131372020-06-24 Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer Jin, Xiao Dai, Lu Ma, Yilan Wang, Jiayan Liu, Zheng Cancer Cell Int Review Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in an oxygen-deficient tumor microenvironment. Numerous studies revealed the central role of HIF-1α in the carcinogenesis and progression of pancreatic cancer. This article reviewed the molecular mechanisms of how HIF-1α regulated tumorigenesis and progression of pancreatic cancer and suggested that targeting HIF-1α and its signaling pathways could be promising therapeutics for pancreatic cancer. BioMed Central 2020-06-24 /pmc/articles/PMC7313137/ /pubmed/32587480 http://dx.doi.org/10.1186/s12935-020-01370-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Jin, Xiao
Dai, Lu
Ma, Yilan
Wang, Jiayan
Liu, Zheng
Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
title Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
title_full Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
title_fullStr Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
title_full_unstemmed Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
title_short Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
title_sort implications of hif-1α in the tumorigenesis and progression of pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313137/
https://www.ncbi.nlm.nih.gov/pubmed/32587480
http://dx.doi.org/10.1186/s12935-020-01370-0
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