Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation

MacroD1 is an enzyme that hydrolyzes protein mono-ADP-ribosylation. However, the key catalytic residues of MacroD1 in these biochemical reactions remain elusive. Here, we present the crystal structure of MacroD1 in a complex with ADP-ribose (ADPR). The β5-α10-loop functions as a switch loop to media...

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Detalles Bibliográficos
Autores principales: Yang, Xiaoyun, Ma, Yinliang, Li, Yimiao, Dong, Yating, Yu, Lily L., Wang, Hong, Guo, Lulin, Wu, Chen, Yu, Xiaochun, Liu, Xiuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313891/
https://www.ncbi.nlm.nih.gov/pubmed/32683309
http://dx.doi.org/10.1016/j.dnarep.2020.102899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313891/
https://www.ncbi.nlm.nih.gov/pubmed/32683309
http://dx.doi.org/10.1016/j.dnarep.2020.102899

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