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Recombinant Human Proteoglycan-4 Mediates Interleukin-6 Response in Both Human and Mouse Endothelial Cells Induced Into a Sepsis Phenotype
OBJECTIVES: Sepsis is a leading cause of death in the United States. Putative targets to prevent systemic inflammatory response syndrome include antagonism of toll-like receptors 2 and 4 and CD44 receptors in vascular endothelial cells. Proteoglycan-4 is a mucinous glycoprotein that interacts with C...
Autores principales: | Richendrfer, Holly A., Levy, Mitchell M., Elsaid, Khaled A., Schmidt, Tannin A., Zhang, Ling, Cabezas, Ralph, Jay, Gregory D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314356/ https://www.ncbi.nlm.nih.gov/pubmed/32695993 http://dx.doi.org/10.1097/CCE.0000000000000126 |
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