Impact of mRNA chemistry and manufacturing process on innate immune activation

Messenger RNA (mRNA) represents an attractive therapeutic modality for potentially a wide range of clinical indications but requires uridine chemistry modification and/or tuning of the production process to prevent activation of cellular innate immune sensors and a concomitant reduction in protein e...

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Detalles Bibliográficos
Autores principales: Nelson, Jennifer, Sorensen, Elizabeth W., Mintri, Shrutika, Rabideau, Amy E., Zheng, Wei, Besin, Gilles, Khatwani, Nikhil, Su, Stephen V., Miracco, Edward J., Issa, William J., Hoge, Stephen, Stanton, Matthew G., Joyal, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314518/
https://www.ncbi.nlm.nih.gov/pubmed/32637598
http://dx.doi.org/10.1126/sciadv.aaz6893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314518/
https://www.ncbi.nlm.nih.gov/pubmed/32637598
http://dx.doi.org/10.1126/sciadv.aaz6893

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