Germline burden of rare damaging variants negatively affects human healthspan and lifespan

Heritability of human lifespan is 23–33% as evident from twin studies. Genome-wide association studies explored this question by linking particular alleles to lifespan traits. However, genetic variants identified so far can explain only a small fraction of lifespan heritability in humans. Here, we r...

Descripción completa

Detalles Bibliográficos
Autores principales: Shindyapina, Anastasia V, Zenin, Aleksandr A, Tarkhov, Andrei E, Santesmasses, Didac, Fedichev, Peter O, Gladyshev, Vadim N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314550/
https://www.ncbi.nlm.nih.gov/pubmed/32254024
http://dx.doi.org/10.7554/eLife.53449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314550/
https://www.ncbi.nlm.nih.gov/pubmed/32254024
http://dx.doi.org/10.7554/eLife.53449

Ejemplares similares