Structural plasticity of SARS-CoV-2 3CL M(pro) active site cavity revealed by room temperature X-ray crystallography

The COVID-19 disease caused by the SARS-CoV-2 coronavirus has become a pandemic health crisis. An attractive target for antiviral inhibitors is the main protease 3CL M(pro) due to its essential role in processing the polyproteins translated from viral RNA. Here we report the room temperature X-ray s...

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Detalles Bibliográficos
Autores principales: Kneller, Daniel W., Phillips, Gwyndalyn, O’Neill, Hugh M., Jedrzejczak, Robert, Stols, Lucy, Langan, Paul, Joachimiak, Andrzej, Coates, Leighton, Kovalevsky, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314768/
https://www.ncbi.nlm.nih.gov/pubmed/32581217
http://dx.doi.org/10.1038/s41467-020-16954-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314768/
https://www.ncbi.nlm.nih.gov/pubmed/32581217
http://dx.doi.org/10.1038/s41467-020-16954-7

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