Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation

Mutations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson’s disease (PD). While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the precise mechanism leading to neurodegeneration in both s...

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Detalles Bibliográficos
Autores principales: Okarmus, Justyna, Bogetofte, Helle, Schmidt, Sissel Ida, Ryding, Matias, García-López, Silvia, Ryan, Brent James, Martínez-Serrano, Alberto, Hyttel, Poul, Meyer, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314796/
https://www.ncbi.nlm.nih.gov/pubmed/32581291
http://dx.doi.org/10.1038/s41598-020-67091-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314796/
https://www.ncbi.nlm.nih.gov/pubmed/32581291
http://dx.doi.org/10.1038/s41598-020-67091-6

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