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Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation
Mutations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson’s disease (PD). While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the precise mechanism leading to neurodegeneration in both s...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314796/ https://www.ncbi.nlm.nih.gov/pubmed/32581291 http://dx.doi.org/10.1038/s41598-020-67091-6 |