Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

The human non-canonical inflammasome controls caspase-4 activation and gasdermin-D-dependent pyroptosis in response to cytosolic bacterial lipopolysaccharide (LPS). Since LPS binds and oligomerizes caspase-4, the pathway is thought to proceed without dedicated LPS sensors or an activation platform....

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Detalles Bibliográficos
Autores principales: Santos, José Carlos, Boucher, Dave, Schneider, Larisa Kapinos, Demarco, Benjamin, Dilucca, Marisa, Shkarina, Kateryna, Heilig, Rosalie, Chen, Kaiwen W., Lim, Roderick Y. H., Broz, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314798/
https://www.ncbi.nlm.nih.gov/pubmed/32581219
http://dx.doi.org/10.1038/s41467-020-16889-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314798/
https://www.ncbi.nlm.nih.gov/pubmed/32581219
http://dx.doi.org/10.1038/s41467-020-16889-z

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