mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division

mTOR activation is essential and sufficient to cause polycystic kidneys in Tuberous Sclerosis Complex (TSC) and other genetic disorders. In disease models, a sharp increase of proliferation and cyst formation correlates with a dramatic loss of oriented cell division (OCD). We find that OCD distortio...

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Detalles Bibliográficos
Autores principales: Bonucci, Martina, Kuperwasser, Nicolas, Barbe, Serena, Koka, Vonda, de Villeneuve, Delphine, Zhang, Chi, Srivastava, Nishit, Jia, Xiaoying, Stokes, Matthew P., Bienaimé, Frank, Verkarre, Virginie, Lopez, Jean Baptiste, Jaulin, Fanny, Pontoglio, Marco, Terzi, Fabiola, Delaval, Benedicte, Piel, Matthieu, Pende, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314806/
https://www.ncbi.nlm.nih.gov/pubmed/32581239
http://dx.doi.org/10.1038/s41467-020-16978-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314806/
https://www.ncbi.nlm.nih.gov/pubmed/32581239
http://dx.doi.org/10.1038/s41467-020-16978-z

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