SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine

The nucleoside analogue nelarabine, the prodrug of arabinosylguanine (AraG), is effective against T-cell acute lymphoblastic leukaemia (T-ALL) but not against B-cell ALL (B-ALL). The underlying mechanisms have remained elusive. Here, data from pharmacogenomics studies and a panel of ALL cell lines r...

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Detalles Bibliográficos
Autores principales: Rothenburger, Tamara, McLaughlin, Katie-May, Herold, Tobias, Schneider, Constanze, Oellerich, Thomas, Rothweiler, Florian, Feber, Andrew, Fenton, Tim R., Wass, Mark N., Keppler, Oliver T., Michaelis, Martin, Cinatl, Jindrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314829/
https://www.ncbi.nlm.nih.gov/pubmed/32581304
http://dx.doi.org/10.1038/s42003-020-1052-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314829/
https://www.ncbi.nlm.nih.gov/pubmed/32581304
http://dx.doi.org/10.1038/s42003-020-1052-8

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