Metformin Protects From Rotenone–Induced Nigrostriatal Neuronal Death in Adult Mice by Activating AMPK-FOXO3 Signaling and Mitigation of Angiogenesis

Parkinson’s disease (PD) is a neurodegenerative disease that affects substantia nigra dopamine neurons. Many studies have documented the role of oxidative stress and angiogenesis in the pathogenesis of PD. Metformin (MTF) is an antidiabetic medication and AMP-activated protein kinase (AMPK) regulato...

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Detalles Bibliográficos
Autores principales: El-Ghaiesh, Sabah H., Bahr, Hoda I., Ibrahiem, Afaf T., Ghorab, Doaa, Alomar, Suliman Y., Farag, Noha E., Zaitone, Sawsan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314970/
https://www.ncbi.nlm.nih.gov/pubmed/32625061
http://dx.doi.org/10.3389/fnmol.2020.00084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314970/
https://www.ncbi.nlm.nih.gov/pubmed/32625061
http://dx.doi.org/10.3389/fnmol.2020.00084

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