The role of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) in the induction of mitochondrial dysfunction in macrophages

A host of chronic inflammatory diseases are accelerated by the formation of the powerful oxidant hypochlorous acid (HOCl) by myeloperoxidase (MPO). In the presence of thiocyanate (SCN(-)), the production of HOCl by MPO is decreased in favour of the formation of a milder oxidant, hypothiocyanous acid...

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Detalles Bibliográficos
Autores principales: Love, Dominic T., Guo, Chaorui, Nikelshparg, Evelina I., Brazhe, Nadezda A., Sosnovtseva, Olga, Hawkins, Clare L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315103/
https://www.ncbi.nlm.nih.gov/pubmed/32570189
http://dx.doi.org/10.1016/j.redox.2020.101602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315103/
https://www.ncbi.nlm.nih.gov/pubmed/32570189
http://dx.doi.org/10.1016/j.redox.2020.101602

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