Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism

Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to differentiate along the myeloid lineage. In this study, we used an HSPC transplantation model to investigate the possible direct interaction of β-glucan and its receptor (dectin-1) on HSPCs in vivo. Purified H...

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Detalles Bibliográficos
Autores principales: Bono, Cristina, Martínez, Alba, Megías, Javier, Gozalbo, Daniel, Yáñez, Alberto, Gil, M. Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315119/
https://www.ncbi.nlm.nih.gov/pubmed/32576672
http://dx.doi.org/10.1128/mBio.00781-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315119/
https://www.ncbi.nlm.nih.gov/pubmed/32576672
http://dx.doi.org/10.1128/mBio.00781-20

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