Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab

Lipoprotein(a) (Lp[a]) is the most common genetically inherited risk factor for cardiovascular disease. Many aspects of Lp(a) metabolism remain unknown. We assessed the uptake of fluorescent Lp(a) in primary human lymphocytes as well as Lp(a) hepatic capture in a mouse model in which endogenous hepa...

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Detalles Bibliográficos
Autores principales: Chemello, Kévin, Beeské, Sandra, Trang Tran, Thi Thu, Blanchard, Valentin, Villard, Elise F., Poirier, Bruno, Le Bail, Jean-Christophe, Dargazanli, Gihad, Ho-Van-Guimbal, Sophie, Boulay, Denis, Bergis, Olivier, Pruniaux, Marie-Pierre, Croyal, Mikaël, Janiak, Philip, Guillot, Etienne, Lambert, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315184/
https://www.ncbi.nlm.nih.gov/pubmed/32613143
http://dx.doi.org/10.1016/j.jacbts.2020.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315184/
https://www.ncbi.nlm.nih.gov/pubmed/32613143
http://dx.doi.org/10.1016/j.jacbts.2020.03.008

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