Overexpression of IκBα in cardiomyocytes alleviates hydrogen peroxide-induced apoptosis and autophagy by inhibiting NF-κB activation

BACKGROUND: Inflammation and oxidative stress play predominant roles in the initiation and progression of ischaemia/reperfusion (I/R) injury, with nuclear factor kappa B (NF-κB) serving as a crucial mediator. Overexpression of the inhibitor of κB alpha (IκBα) gene is hypothesized to have protective...

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Detalles Bibliográficos
Autores principales: Han, Min, Chen, Xiao-Cui, Sun, Ming-Hui, Gai, Min-Tao, Yang, Yi-Ning, Gao, Xiao-Ming, Ma, Xiang, Chen, Bang-Dang, Ma, Yi-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315514/
https://www.ncbi.nlm.nih.gov/pubmed/32580730
http://dx.doi.org/10.1186/s12944-020-01327-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315514/
https://www.ncbi.nlm.nih.gov/pubmed/32580730
http://dx.doi.org/10.1186/s12944-020-01327-2

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