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Promoter Hypermethylation of Wnt/β-catenin Signaling Pathway Inhibitor WIF-1 Gene and its Association with MTHFR C677T Polymorphism in Patients with Colorectal Cancer

OBJECTIVES: Colorectal cancer (CRC) is a common malignancy with a high rate of mortality. The dysregulation of genes involved in the Wnt/β-catenin signaling pathway is a common finding in cancers. Wnt-inhibitory factor-1 (WIF-1) suppresses the Wnt/β-catenin signaling pathway and its inactivation by...

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Detalles Bibliográficos
Autores principales: Jalilvand, Ahmad, Soltanpour, Mohammad Soleiman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OMJ 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315525/
https://www.ncbi.nlm.nih.gov/pubmed/32607254
http://dx.doi.org/10.5001/omj.2020.49