Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease

[Image: see text] Sickle cell disease (SCD) is caused by a single nucleotide polymorphism on chromosome 11 in the β-globin gene. The resulting mutant hemoglobin S (HbS) is a poor oxygen transporter and causes a variety of vascular symptoms and organ failures. At birth, the DRED epigenetic complex fo...

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Detalles Bibliográficos
Autores principales: Holshouser, Steven, Cafiero, Rebecca, Robinson, Mayra, Kirkpatrick, Joy, Casero, Robert A., Hyacinth, Hyacinth I., Woster, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315572/
https://www.ncbi.nlm.nih.gov/pubmed/32596612
http://dx.doi.org/10.1021/acsomega.0c01585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315572/
https://www.ncbi.nlm.nih.gov/pubmed/32596612
http://dx.doi.org/10.1021/acsomega.0c01585

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