The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, a subunit of the Golgi-associated retrograde protein (GARP) complex that identifies a function of LRRK2 in regul...

Descripción completa

Detalles Bibliográficos
Autores principales: Beilina, Alexandra, Bonet-Ponce, Luis, Kumaran, Ravindran, Kordich, Jennifer J., Ishida, Morié, Mamais, Adamantios, Kaganovich, Alice, Saez-Atienzar, Sara, Gershlick, David C., Roosen, Dorien A., Pellegrini, Laura, Malkov, Vlad, Fell, Matthew J., Harvey, Kirsten, Bonifacino, Juan S., Moore, Darren J., Cookson, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315779/
https://www.ncbi.nlm.nih.gov/pubmed/32375042
http://dx.doi.org/10.1016/j.celrep.2020.107614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315779/
https://www.ncbi.nlm.nih.gov/pubmed/32375042
http://dx.doi.org/10.1016/j.celrep.2020.107614

Ejemplares similares