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Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

[Image: see text] While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lung...

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Detalles Bibliográficos
Autores principales:	Yan, Victoria C., Muller, Florian L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315846/ https://www.ncbi.nlm.nih.gov/pubmed/32665809 http://dx.doi.org/10.1021/acsmedchemlett.0c00316

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