Implications of localized charge for human influenza A H1N1 hemagglutinin evolution: Insights from deep mutational scans

Seasonal influenza A viruses of humans evolve rapidly due to strong selection pressures from host immune responses, principally on the hemagglutinin (HA) viral surface protein. Based on mouse transmission experiments, a proposed mechanism for immune evasion consists of increased avidity to host cell...

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Detalles Bibliográficos
Autores principales: Saad-Roy, Chadi M., Arinaminpathy, Nimalan, Wingreen, Ned S., Levin, Simon A., Akey, Joshua M., Grenfell, Bryan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316228/
https://www.ncbi.nlm.nih.gov/pubmed/32584807
http://dx.doi.org/10.1371/journal.pcbi.1007892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316228/
https://www.ncbi.nlm.nih.gov/pubmed/32584807
http://dx.doi.org/10.1371/journal.pcbi.1007892

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