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EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice

EBV transforms B cells in vitro and causes human B-cell lymphomas including classical Hodgkin lymphoma (CHL), Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). The EBV latency protein, EBNA2, transcriptionally activates the promoters of all latent viral protein-coding genes expressed...

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Detalles Bibliográficos
Autores principales: Li, Chunrong, Romero-Masters, James C., Huebner, Shane, Ohashi, Makoto, Hayes, Mitchell, Bristol, Jillian A., Nelson, Scott E., Eichelberg, Mark R., Van Sciver, Nicholas, Ranheim, Erik A., Scott, Rona S., Johannsen, Eric C., Kenney, Shannon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316346/
https://www.ncbi.nlm.nih.gov/pubmed/32542010
http://dx.doi.org/10.1371/journal.ppat.1008590