Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism

FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism. Mutations in FANCJ are associated with Fanconi anemia and an increased risk for developing breast and ovarian cancer. Several cancer-associated muta...

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Detalles Bibliográficos
Autores principales: Odermatt, Diana C., Lee, Wei Ting C., Wild, Sebastian, Jozwiakowski, Stanislaw K., Rothenberg, Eli, Gari, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316351/
https://www.ncbi.nlm.nih.gov/pubmed/32542039
http://dx.doi.org/10.1371/journal.pgen.1008740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316351/
https://www.ncbi.nlm.nih.gov/pubmed/32542039
http://dx.doi.org/10.1371/journal.pgen.1008740

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