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Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism
FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism. Mutations in FANCJ are associated with Fanconi anemia and an increased risk for developing breast and ovarian cancer. Several cancer-associated muta...
Autores principales: | Odermatt, Diana C., Lee, Wei Ting C., Wild, Sebastian, Jozwiakowski, Stanislaw K., Rothenberg, Eli, Gari, Kerstin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316351/ https://www.ncbi.nlm.nih.gov/pubmed/32542039 http://dx.doi.org/10.1371/journal.pgen.1008740 |
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