Cargando…

Kilohertz waveforms optimized to produce closed-state Na(+) channel inactivation eliminate onset response in nerve conduction block

The delivery of kilohertz frequency alternating current (KHFAC) generates rapid, controlled, and reversible conduction block in motor, sensory, and autonomic nerves, but causes transient activation of action potentials at the onset of the blocking current. We implemented a novel engineering optimiza...

Descripción completa

Detalles Bibliográficos
Autores principales: Yi, Guosheng, Grill, Warren M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316353/
https://www.ncbi.nlm.nih.gov/pubmed/32542050
http://dx.doi.org/10.1371/journal.pcbi.1007766