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Kilohertz waveforms optimized to produce closed-state Na(+) channel inactivation eliminate onset response in nerve conduction block
The delivery of kilohertz frequency alternating current (KHFAC) generates rapid, controlled, and reversible conduction block in motor, sensory, and autonomic nerves, but causes transient activation of action potentials at the onset of the blocking current. We implemented a novel engineering optimiza...
Autores principales: | Yi, Guosheng, Grill, Warren M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316353/ https://www.ncbi.nlm.nih.gov/pubmed/32542050 http://dx.doi.org/10.1371/journal.pcbi.1007766 |
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