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Estimation of non-null SNP effect size distributions enables the detection of enriched genes underlying complex traits
Traditional univariate genome-wide association studies generate false positives and negatives due to difficulties distinguishing associated variants from variants with spurious nonzero effects that do not directly influence the trait. Recent efforts have been directed at identifying genes or signali...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316356/ https://www.ncbi.nlm.nih.gov/pubmed/32542026 http://dx.doi.org/10.1371/journal.pgen.1008855 |