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Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans
While the folate biosynthetic pathway has provided a rich source of antibacterial, antiprotozoal, and anticancer therapies, it has not yet been exploited to develop uniquely antifungal agents. Although there have been attempts to develop fungal-specific inhibitors of dihydrofolate reductase (DHFR),...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316490/ https://www.ncbi.nlm.nih.gov/pubmed/32581079 http://dx.doi.org/10.1128/mSphere.00374-20 |