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Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus
Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that PVN leptin slowly increases SNA to muscle and brown adipose tissue, because it induces the expression of its own recept...
Autores principales: | Shi, Zhigang, Pelletier, Nicole E, Wong, Jennifer, Li, Baoxin, Sdrulla, Andrei D, Madden, Christopher J, Marks, Daniel L, Brooks, Virginia L |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316512/ https://www.ncbi.nlm.nih.gov/pubmed/32538782 http://dx.doi.org/10.7554/eLife.55357 |
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