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Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins
[Image: see text] Monobodies are small engineered binding proteins that, upon expression in cells, can inhibit signaling of cytosolic oncoproteins with outstanding selectivity. Efficacy may be further increased by inducing degradation of monobody targets through fusion to the von Hippel–Lindau (VHL)...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316569/ https://www.ncbi.nlm.nih.gov/pubmed/31025848 http://dx.doi.org/10.1021/acschembio.9b00113 |