Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells

Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate in Type 2 diabetes (T2D) and Alzheimer’s disease (AD) brains and evidence suggests that interaction between the two amyloidogenic proteins can lead to the formation of heterocomplex aggregates. However, the struc...

Descripción completa

Detalles Bibliográficos
Autores principales: Bharadwaj, Prashant, Solomon, Tanya, Sahoo, Bikash R., Ignasiak, Katarzyna, Gaskin, Scott, Rowles, Joanne, Verdile, Giuseppe, Howard, Mark J., Bond, Charles S., Ramamoorthy, Ayyalusamy, Martins, Ralph N., Newsholme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316712/
https://www.ncbi.nlm.nih.gov/pubmed/32587390
http://dx.doi.org/10.1038/s41598-020-66602-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316712/
https://www.ncbi.nlm.nih.gov/pubmed/32587390
http://dx.doi.org/10.1038/s41598-020-66602-9

Ejemplares similares