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Iron stored in ferritin is chemically reduced in the presence of aggregating Aβ(1-42)
Atypical low-oxidation-state iron phases in Alzheimer’s disease (AD) pathology are implicated in disease pathogenesis, as they may promote elevated redox activity and convey toxicity. However, the origin of low-oxidation-state iron and the pathways responsible for its formation and evolution remain...
Autores principales: | Everett, James, Brooks, Jake, Lermyte, Frederik, O’Connor, Peter B., Sadler, Peter J., Dobson, Jon, Collingwood, Joanna F., Telling, Neil D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316746/ https://www.ncbi.nlm.nih.gov/pubmed/32587293 http://dx.doi.org/10.1038/s41598-020-67117-z |
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