Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases. By substituting a serine r...

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Detalles Bibliográficos
Autores principales: van der Wel, Tom, Hilhorst, Riet, den Dulk, Hans, van den Hooven, Tim, Prins, Nienke M., Wijnakker, Joost A. P. M., Florea, Bogdan I., Lenselink, Eelke B., van Westen, Gerard J. P., Ruijtenbeek, Rob, Overkleeft, Herman S., Kaptein, Allard, Barf, Tjeerd, van der Stelt, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316778/
https://www.ncbi.nlm.nih.gov/pubmed/32587248
http://dx.doi.org/10.1038/s41467-020-17027-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316778/
https://www.ncbi.nlm.nih.gov/pubmed/32587248
http://dx.doi.org/10.1038/s41467-020-17027-5

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