Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models

Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by loss of the survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration of spinal cord motoneurons (MNs), progressive skeletal muscle atrophy, and weakness. The cellular and molecular mechanisms causing MN l...

Descripción completa

Detalles Bibliográficos
Autores principales: de la Fuente, Sandra, Sansa, Alba, Hidalgo, Iván, Vivancos, Nuria, Romero-Guevara, Ricardo, Garcera, Ana, Soler, Rosa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316821/
https://www.ncbi.nlm.nih.gov/pubmed/32587237
http://dx.doi.org/10.1038/s41419-020-2688-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316821/
https://www.ncbi.nlm.nih.gov/pubmed/32587237
http://dx.doi.org/10.1038/s41419-020-2688-5

Ejemplares similares