Monosomal karyotype and chromosome 17p loss or TP53 mutations in decitabine-treated patients with acute myeloid leukemia

TP53 aberrations reportedly predict favorable responses to decitabine (DAC) in acute myeloid leukemia (AML). We evaluated clinical features and outcomes associated with chromosome 17p loss or TP53 gene mutations in older, unfit DAC-treated AML patients in a phase II trial. Of 178 patients, 25 had lo...

Descripción completa

Detalles Bibliográficos
Autores principales: Becker, Heiko, Pfeifer, Dietmar, Ihorst, Gabriele, Pantic, Milena, Wehrle, Julius, Rüter, Björn H., Bullinger, Lars, Hackanson, Björn, Germing, Ulrich, Kuendgen, Andrea, Platzbecker, Uwe, Döhner, Konstanze, Ganser, Arnold, Hagemeijer, Anne, Wijermans, Pierre W., Döhner, Hartmut, Duyster, Justus, Lübbert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316846/
https://www.ncbi.nlm.nih.gov/pubmed/32504186
http://dx.doi.org/10.1007/s00277-020-04082-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316846/
https://www.ncbi.nlm.nih.gov/pubmed/32504186
http://dx.doi.org/10.1007/s00277-020-04082-7

Ejemplares similares