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Monosomal karyotype and chromosome 17p loss or TP53 mutations in decitabine-treated patients with acute myeloid leukemia
TP53 aberrations reportedly predict favorable responses to decitabine (DAC) in acute myeloid leukemia (AML). We evaluated clinical features and outcomes associated with chromosome 17p loss or TP53 gene mutations in older, unfit DAC-treated AML patients in a phase II trial. Of 178 patients, 25 had lo...
Autores principales: | Becker, Heiko, Pfeifer, Dietmar, Ihorst, Gabriele, Pantic, Milena, Wehrle, Julius, Rüter, Björn H., Bullinger, Lars, Hackanson, Björn, Germing, Ulrich, Kuendgen, Andrea, Platzbecker, Uwe, Döhner, Konstanze, Ganser, Arnold, Hagemeijer, Anne, Wijermans, Pierre W., Döhner, Hartmut, Duyster, Justus, Lübbert, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316846/ https://www.ncbi.nlm.nih.gov/pubmed/32504186 http://dx.doi.org/10.1007/s00277-020-04082-7 |
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