Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells

Polymorphisms in the Complement Factor H (CFH) gene, coding for the Factor H protein (FH), can increase the risk for age-related macular degeneration (AMD). AMD-associated CFH risk variants, Y402H in particular, impair FH function leading to complement overactivation. Whether this alone suffices to...

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Detalles Bibliográficos
Autores principales: Armento, Angela, Honisch, Sabina, Panagiotakopoulou, Vasiliki, Sonntag, Inga, Jacob, Anke, Bolz, Sylvia, Kilger, Ellen, Deleidi, Michela, Clark, Simon, Ueffing, Marius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316856/
https://www.ncbi.nlm.nih.gov/pubmed/32587311
http://dx.doi.org/10.1038/s41598-020-67292-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316856/
https://www.ncbi.nlm.nih.gov/pubmed/32587311
http://dx.doi.org/10.1038/s41598-020-67292-z

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