TET1 Deficiency Impairs Morphogen-free Differentiation of Human Embryonic Stem Cells to Neuroectoderm

The TET family of 5-methylcytosine (5mC) dioxygenases plays critical roles in development by modifying DNA methylation. Using CRISPR, we inactivated the TET1 gene in H9 human embryonic stem cells (hESCs). Mutant H9 hESCs remained pluripotent, even though the level of hydroxymethylcytosine (5hmC) dec...

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Detalles Bibliográficos
Autores principales: Li, Hanqin, Hu, Zhixing, Jiang, Houbo, Pu, Jiali, Selli, Ilana, Qiu, Jingxin, Zhang, Baorong, Feng, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316867/
https://www.ncbi.nlm.nih.gov/pubmed/32587369
http://dx.doi.org/10.1038/s41598-020-67143-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316867/
https://www.ncbi.nlm.nih.gov/pubmed/32587369
http://dx.doi.org/10.1038/s41598-020-67143-x

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