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Mathematical modeling of the ‘inoculum effect': six applicable models and the MIC advancement point concept
Antimicrobial treatment regimens against bacterial pathogens are designed using the drug's minimum inhibitory concentration (MIC) measured at a bacterial density of 5.7 log(10)(colony-forming units (CFU)/mL) in vitro. However, MIC changes with pathogen density, which varies among infectious dis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317156/ https://www.ncbi.nlm.nih.gov/pubmed/31960902 http://dx.doi.org/10.1093/femsle/fnaa012 |