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Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0
A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geogra...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317522/ https://www.ncbi.nlm.nih.gov/pubmed/31970929 http://dx.doi.org/10.1111/tan.13811 |
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author | Hurley, Carolyn K. Kempenich, Jane Wadsworth, Kim Sauter, Jürgen Hofmann, Jan A. Schefzyk, Daniel Schmidt, Alexander H. Galarza, Pablo Cardozo, Maria B. R. Dudkiewicz, Malgorzata Houdova, Lucie Jindra, Pavel Sorensen, Betina S. Jagannathan, Latha Mathur, Ankit Linjama, Tiina Torosian, Tigran Freudenberger, Rafi Manolis, Anastasios Mavrommatis, John Cereb, Nezih Manor, Sigal Shriki, Nira Sacchi, Nicoletta Ameen, Reem Fisher, Raewyn Dunckley, Heather Andersen, Irene Alaskar, Ahmed Alzahrani, Mohsen Hajeer, Ali Jawdat, Dunia Nicoloso, Grazia Kupatawintu, Pawinee Cho, Louise Kaur, Ashminder Bengtsson, Mats Dehn, Jason |
author_facet | Hurley, Carolyn K. Kempenich, Jane Wadsworth, Kim Sauter, Jürgen Hofmann, Jan A. Schefzyk, Daniel Schmidt, Alexander H. Galarza, Pablo Cardozo, Maria B. R. Dudkiewicz, Malgorzata Houdova, Lucie Jindra, Pavel Sorensen, Betina S. Jagannathan, Latha Mathur, Ankit Linjama, Tiina Torosian, Tigran Freudenberger, Rafi Manolis, Anastasios Mavrommatis, John Cereb, Nezih Manor, Sigal Shriki, Nira Sacchi, Nicoletta Ameen, Reem Fisher, Raewyn Dunckley, Heather Andersen, Irene Alaskar, Ahmed Alzahrani, Mohsen Hajeer, Ali Jawdat, Dunia Nicoloso, Grazia Kupatawintu, Pawinee Cho, Louise Kaur, Ashminder Bengtsson, Mats Dehn, Jason |
author_sort | Hurley, Carolyn K. |
collection | PubMed |
description | A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two‐field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well‐documented (≥5 occurrences) or not‐CIWD. Overall 26% of alleles in IPD‐IMGT/HLA version 3.31.0 at P group resolution fall into the three CIWD categories. The two‐field catalog includes 18% (n = 545) common, 17% (n = 513) intermediate, and 65% (n = 1997) well‐documented alleles. Full‐field allele frequency data are provided but are limited in value by the variations in resolution used by the registries. A recommended CIWD list is based on the most frequent category in the total or any of the seven geographic/ancestral/ethnic groups. Data are also provided so users can compile a catalog specific to the population groups that they serve. Comparisons are made to three previous CWD reports representing more limited population groups. This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole. |
format | Online Article Text |
id | pubmed-7317522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-73175222020-06-30 Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0 Hurley, Carolyn K. Kempenich, Jane Wadsworth, Kim Sauter, Jürgen Hofmann, Jan A. Schefzyk, Daniel Schmidt, Alexander H. Galarza, Pablo Cardozo, Maria B. R. Dudkiewicz, Malgorzata Houdova, Lucie Jindra, Pavel Sorensen, Betina S. Jagannathan, Latha Mathur, Ankit Linjama, Tiina Torosian, Tigran Freudenberger, Rafi Manolis, Anastasios Mavrommatis, John Cereb, Nezih Manor, Sigal Shriki, Nira Sacchi, Nicoletta Ameen, Reem Fisher, Raewyn Dunckley, Heather Andersen, Irene Alaskar, Ahmed Alzahrani, Mohsen Hajeer, Ali Jawdat, Dunia Nicoloso, Grazia Kupatawintu, Pawinee Cho, Louise Kaur, Ashminder Bengtsson, Mats Dehn, Jason HLA Original Articles A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two‐field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well‐documented (≥5 occurrences) or not‐CIWD. Overall 26% of alleles in IPD‐IMGT/HLA version 3.31.0 at P group resolution fall into the three CIWD categories. The two‐field catalog includes 18% (n = 545) common, 17% (n = 513) intermediate, and 65% (n = 1997) well‐documented alleles. Full‐field allele frequency data are provided but are limited in value by the variations in resolution used by the registries. A recommended CIWD list is based on the most frequent category in the total or any of the seven geographic/ancestral/ethnic groups. Data are also provided so users can compile a catalog specific to the population groups that they serve. Comparisons are made to three previous CWD reports representing more limited population groups. This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole. Blackwell Publishing Ltd 2020-01-31 2020-06 /pmc/articles/PMC7317522/ /pubmed/31970929 http://dx.doi.org/10.1111/tan.13811 Text en © 2020 The Authors. HLA published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Hurley, Carolyn K. Kempenich, Jane Wadsworth, Kim Sauter, Jürgen Hofmann, Jan A. Schefzyk, Daniel Schmidt, Alexander H. Galarza, Pablo Cardozo, Maria B. R. Dudkiewicz, Malgorzata Houdova, Lucie Jindra, Pavel Sorensen, Betina S. Jagannathan, Latha Mathur, Ankit Linjama, Tiina Torosian, Tigran Freudenberger, Rafi Manolis, Anastasios Mavrommatis, John Cereb, Nezih Manor, Sigal Shriki, Nira Sacchi, Nicoletta Ameen, Reem Fisher, Raewyn Dunckley, Heather Andersen, Irene Alaskar, Ahmed Alzahrani, Mohsen Hajeer, Ali Jawdat, Dunia Nicoloso, Grazia Kupatawintu, Pawinee Cho, Louise Kaur, Ashminder Bengtsson, Mats Dehn, Jason Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0 |
title | Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0 |
title_full | Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0 |
title_fullStr | Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0 |
title_full_unstemmed | Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0 |
title_short | Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0 |
title_sort | common, intermediate and well‐documented hla alleles in world populations: ciwd version 3.0.0 |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317522/ https://www.ncbi.nlm.nih.gov/pubmed/31970929 http://dx.doi.org/10.1111/tan.13811 |
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