Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage‐mediated extracellular matrix remodeling

Obesity is a risk factor for breast cancer in postmenopausal and high‐risk premenopausal women. Changes within the obese breast microenvironment may increase breast cancer risk. Transforming growth factor beta‐1 (TGFβ1) is a major regulator of mammary epithelial stem/progenitor cells, and its activi...

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Detalles Bibliográficos
Autores principales: Chamberlin, Tamara, Thompson, Victoria, Hillers‐Ziemer, Lauren E., Walton, Brenna N., Arendt, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317547/
https://www.ncbi.nlm.nih.gov/pubmed/32359100
http://dx.doi.org/10.1096/fj.202000228RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317547/
https://www.ncbi.nlm.nih.gov/pubmed/32359100
http://dx.doi.org/10.1096/fj.202000228RR

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