Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery

Increased protein synthesis is a key process in melanoma, which is regulated by the ALDH18A1 gene encoding pyrroline-5-carboxylate synthase (P5CS). P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular pr...

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Detalles Bibliográficos
Autores principales: Kardos, Gregory R., Gowda, Raghavendra, Dinavahi, Saketh Sriram, Kimball, Scot, Robertson, Gavin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317660/
https://www.ncbi.nlm.nih.gov/pubmed/32637352
http://dx.doi.org/10.3389/fonc.2020.00834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317660/
https://www.ncbi.nlm.nih.gov/pubmed/32637352
http://dx.doi.org/10.3389/fonc.2020.00834

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