PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice

OBJECTIVE: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used as anti-diabetic drugs and are approved for obesity treatment. However, GLP-1RAs also affect heart rate (HR) and arterial blood pressure (ABP) in rodents and humans. Although the activation of GLP-1 receptors (GLP-1R) is known...

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Detalles Bibliográficos
Autores principales: Holt, Marie K., Cook, Daniel R., Brierley, Daniel I., Richards, James E., Reimann, Frank, Gourine, Alexander V., Marina, Nephtali, Trapp, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317700/
https://www.ncbi.nlm.nih.gov/pubmed/32446875
http://dx.doi.org/10.1016/j.molmet.2020.101024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317700/
https://www.ncbi.nlm.nih.gov/pubmed/32446875
http://dx.doi.org/10.1016/j.molmet.2020.101024

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