The TGF‐b/SOX4 axis and ROS‐driven autophagy co‐mediate CD39 expression in regulatory T‐cells

The ectonucleotidase CD39 on human regulatory T‐cells (Treg) is an important immune regulator which is dysregulated in autoimmune diseases and cancer immunosuppression. We here define that CD39 expression on Treg is independent of the Treg‐specific transcription factors FOXP3 and HELIOS and promoted...

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Detalles Bibliográficos
Autores principales: Gerner, Marlene C., Ziegler, Liesa S., Schmidt, Ralf L. J., Krenn, Martin, Zimprich, Fritz, Uyanik‐Ünal, Keziban, Konstantopoulou, Vassiliki, Derdak, Sophia, Del Favero, Giorgia, Schwarzinger, Ilse, Boztug, Kaan, Schmetterer, Klaus G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317981/
https://www.ncbi.nlm.nih.gov/pubmed/32319705
http://dx.doi.org/10.1096/fj.201902664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317981/
https://www.ncbi.nlm.nih.gov/pubmed/32319705
http://dx.doi.org/10.1096/fj.201902664

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