Mechanisms of γ-Secretase Activation and Substrate Processing

[Image: see text] Amyloid β-peptide, the principal component of characteristic cerebral plaques of Alzheimer’s disease (AD), is produced through intramembrane proteolysis of the amyloid precursor protein (APP) by γ-secretase. Despite the importance in the pathogenesis of AD, the mechanisms of intram...

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Detalles Bibliográficos
Autores principales: Bhattarai, Apurba, Devkota, Sujan, Bhattarai, Sanjay, Wolfe, Michael S., Miao, Yinglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318072/
https://www.ncbi.nlm.nih.gov/pubmed/32607444
http://dx.doi.org/10.1021/acscentsci.0c00296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318072/
https://www.ncbi.nlm.nih.gov/pubmed/32607444
http://dx.doi.org/10.1021/acscentsci.0c00296

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