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Mechanisms of γ-Secretase Activation and Substrate Processing
[Image: see text] Amyloid β-peptide, the principal component of characteristic cerebral plaques of Alzheimer’s disease (AD), is produced through intramembrane proteolysis of the amyloid precursor protein (APP) by γ-secretase. Despite the importance in the pathogenesis of AD, the mechanisms of intram...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318072/ https://www.ncbi.nlm.nih.gov/pubmed/32607444 http://dx.doi.org/10.1021/acscentsci.0c00296 |